| 9/4/2021 | Finlandia (0-9) | 6 | at | Lawrence | 42 | MIAA | ||
| 9/11/2021 | Lawrence | 26 | at | Lake Forest (10-1,9-0) | 52 | |||
| 9/18/2021 | Lawrence | 28 | at | Grinnell (2-8,2-7) | 35 | OT | ||
| 10/2/2021 | Monmouth IL (8-2,8-1) | 42 | at | Lawrence | 0 | |||
| 10/9/2021 | Lawrence | 24 | at | Cornell IA (4-6,4-5) | 35 | |||
| 10/16/2021 | Illinois College (5-5,5-4) | 38 | at | Lawrence | 37 | |||
| 10/23/2021 | Beloit (0-10,0-9) | 21 | at | Lawrence | 43 | |||
| 10/30/2021 | Lawrence | 28 | at | Knox (3-6,3-6) | 56 | |||
| 11/6/2021 | Lawrence | 0 | at | Chicago (8-2,7-2) | 66 | |||
| 11/13/2021 | Ripon (6-3,5-3) | at | Lawrence | Cancelled |
| vs Lawrence | vs Other Opponents | Lawrence compared to OOs | |
| Record: | 7-2 | 39-50 | |
| Points Scored: | 39.00 | 25.30 | -13.70 |
| Points Allowed: | 25.33 | 29.17 | -3.84 |
| Margin: | 13.67 | -3.87 | -17.54 |
| Total Points: | 64.33 | 54.47 | 9.86 |