| 9/4/2021 | Ill. Benedictine | 34 | at | Kenyon (3-7) | 31 | OT | at NCA | |
| 9/11/2021 | Carroll WI (6-4) | 35 | at | Ill. Benedictine | 24 | CCIW | ||
| 9/18/2021 | Ill. Benedictine | 31 | at | Concordia WI (6-4,4-4) | 20 | |||
| 9/25/2021 | Eureka (2-8,2-6) | 29 | at | Ill. Benedictine | 49 | |||
| 10/2/2021 | Ill. Benedictine | 41 | at | St Norbert (5-5,4-4) | 34 | |||
| 10/9/2021 | Lakeland (8-2,6-2) | 40 | at | Ill. Benedictine | 54 | |||
| 10/23/2021 | Rockford (2-8,1-7) | 34 | at | Ill. Benedictine | 41 | |||
| 10/30/2021 | Ill. Benedictine | 41 | at | Aurora (8-3,8-0) | 63 | |||
| 11/6/2021 | Concordia IL (3-7,1-7) | 21 | at | Ill. Benedictine | 49 | |||
| 11/13/2021 | Ill. Benedictine | 51 | at | Wisconsin Lutheran (3-7,3-5) | 49 |
| vs Ill. Benedictine | vs Other Opponents | Ill. Benedictine compared to OOs | |
| Record: | 2-8 | 44-47 | |
| Points Scored: | 35.60 | 30.27 | -5.33 |
| Points Allowed: | 41.50 | 34.43 | 7.07 |
| Margin: | -5.90 | -4.16 | 1.74 |
| Total Points: | 77.10 | 64.70 | 12.40 |