| 9/18/2021 | Wesleyan (6-3,6-3) | 21 | at | Colby | 5 | |||
| 9/25/2021 | Colby | 10 | at | Amherst (5-4,5-4) | 7 | |||
| 10/2/2021 | Hamilton (2-7,2-7) | 27 | at | Colby | 14 | |||
| 10/9/2021 | Colby | 0 | at | Williams (9-0,9-0) | 42 | |||
| 10/16/2021 | Middlebury (3-6,3-6) | 14 | at | Colby | 28 | |||
| 10/23/2021 | Trinity CT (8-1,8-1) | 35 | at | Colby | 12 | |||
| 10/30/2021 | Colby | 10 | at | Bates (3-6,3-6) | 2 | |||
| 11/6/2021 | Colby | 21 | at | Tufts (4-5,4-5) | 26 | |||
| 11/13/2021 | Bowdoin (1-8,1-8) | 10 | at | Colby | 21 |
| vs Colby | vs Other Opponents | Colby compared to OOs | |
| Record: | 5-4 | 36-36 | |
| Points Scored: | 20.44 | 22.31 | 1.87 |
| Points Allowed: | 13.44 | 22.31 | -8.87 |
| Margin: | 7.00 | 0.00 | -7.00 |
| Total Points: | 33.88 | 44.62 | -10.74 |