| 9/2/2021 | American Int'l | 14 | at | Millersville (2-9) | 9 | at PSAC | ||
| 9/10/2021 | American Int'l | 40 | at | Pace (2-8,2-7) | 33 | |||
| 9/18/2021 | American Int'l | 38 | at | Franklin Pierce (0-10,0-9) | 19 | |||
| 9/25/2021 | Bentley (9-2,8-2) | 35 | at | American Int'l | 27 | |||
| 10/1/2021 | American Int'l | 7 | at | Southern Connecticut (4-6,3-6) | 23 | |||
| 10/9/2021 | Stonehill (8-2,7-2) | 25 | at | American Int'l | 0 | |||
| 10/16/2021 | New Haven (10-2,10-0) | 30 | at | American Int'l | 14 | |||
| 10/23/2021 | American Int'l | 21 | at | Assumption (5-5,5-4) | 42 | |||
| 10/30/2021 | American Int'l | 16 | at | Saint Anselm (3-6,3-5) | 21 | |||
| 11/13/2021 | Pace (2-8,2-7) | 7 | at | American Int'l | 14 |
| vs American Int'l | vs Other Opponents | American Int'l compared to OOs | |
| Record: | 6-4 | 39-52 | |
| Points Scored: | 24.40 | 23.45 | -0.95 |
| Points Allowed: | 19.10 | 26.93 | -7.83 |
| Margin: | 5.30 | -3.48 | -8.78 |
| Total Points: | 43.50 | 50.38 | -6.88 |