| 9/4/2021 | Penn State | 16 | at | Wisconsin (9-4,6-3) | 10 | |||
| 9/11/2021 | Ball State (6-7) | 13 | at | Penn State | 44 | MAC | ||
| 9/18/2021 | Auburn (6-7) | 20 | at | Penn State | 28 | SEC | ||
| 9/25/2021 | Villanova (10-3) | 17 | at | Penn State | 38 | CAAF (1AA) | ||
| 10/2/2021 | Indiana (2-10,0-9) | 0 | at | Penn State | 24 | |||
| 10/9/2021 | Penn State | 20 | at | Iowa (10-4,7-3) | 23 | |||
| 10/23/2021 | Illinois (5-7,4-5) | 20 | at | Penn State | 18 | 9OT | ||
| 10/30/2021 | Penn State | 24 | at | Ohio State (11-2,8-1) | 33 | |||
| 11/6/2021 | Penn State | 31 | at | Maryland (7-6,3-6) | 14 | |||
| 11/13/2021 | Michigan (12-2,9-1) | 21 | at | Penn State | 17 | |||
| 11/20/2021 | Rutgers (5-8,2-7) | 0 | at | Penn State | 28 | |||
| 11/27/2021 | Penn State | 27 | at | Michigan State (11-2,7-2) | 30 | |||
| 1/1/2022 | Penn State | 10 | vs | Arkansas (9-4) | 24 | Outback Bowl - Tampa FL | vs SEC |
| vs Penn State | vs Other Opponents | Penn State compared to OOs | |
| Record: | 6-7 | 97-59 | |
| Points Scored: | 17.31 | 28.86 | 11.55 |
| Points Allowed: | 25.00 | 22.97 | 2.03 |
| Margin: | -7.69 | 5.89 | 13.58 |
| Total Points: | 42.31 | 51.83 | -9.52 |