| 9/4/2021 | Rice (4-8) | 17 | at | Arkansas | 38 | CUSA | ||
| 9/11/2021 | Texas (5-7) | 21 | at | Arkansas | 40 | B12 | ||
| 9/18/2021 | Georgia Southern (3-9) | 10 | at | Arkansas | 45 | SBC | ||
| 9/25/2021 | Texas A&M (8-4,4-4) | 10 | vs | Arkansas | 20 | Arlington TX | ||
| 10/2/2021 | Arkansas | 0 | at | Georgia (14-1,9-1) | 37 | |||
| 10/9/2021 | Arkansas | 51 | at | Mississippi (10-3,6-2) | 52 | |||
| 10/16/2021 | Auburn (6-7,3-5) | 38 | at | Arkansas | 23 | |||
| 10/23/2021 | Ark Pine Bluff (2-9) | 3 | vs | Arkansas | 45 | Little Rock AR | SWAC (1AA) | |
| 11/6/2021 | Mississippi State (7-6,4-4) | 28 | at | Arkansas | 31 | |||
| 11/13/2021 | Arkansas | 16 | at | LSU (6-7,3-5) | 13 | OT | ||
| 11/20/2021 | Arkansas | 35 | at | Alabama (13-2,8-2) | 42 | |||
| 11/26/2021 | Missouri (6-7,3-5) | 17 | at | Arkansas | 34 | |||
| 1/1/2022 | Penn State (7-6) | 10 | vs | Arkansas | 24 | Outback Bowl - Tampa FL | B10 |
| vs Arkansas | vs Other Opponents | Arkansas compared to OOs | |
| Record: | 4-9 | 87-67 | |
| Points Scored: | 22.92 | 29.90 | 6.98 |
| Points Allowed: | 30.92 | 24.64 | 6.28 |
| Margin: | -8.00 | 5.26 | 13.26 |
| Total Points: | 53.84 | 54.54 | -0.70 |