| 9/4/2021 | Temple (3-9) | 14 | at | Rutgers | 61 | AAC | ||
| 9/11/2021 | Rutgers | 17 | at | Syracuse (5-7) | 7 | at ACC | ||
| 9/18/2021 | Delaware (5-6) | 13 | at | Rutgers | 45 | CAAF (1AA) | ||
| 9/25/2021 | Rutgers | 13 | at | Michigan (12-2,9-1) | 20 | |||
| 10/2/2021 | Ohio State (11-2,8-1) | 52 | at | Rutgers | 13 | |||
| 10/9/2021 | Michigan State (11-2,7-2) | 31 | at | Rutgers | 13 | |||
| 10/16/2021 | Rutgers | 7 | at | Northwestern (3-9,1-8) | 21 | |||
| 10/30/2021 | Rutgers | 20 | at | Illinois (5-7,4-5) | 14 | |||
| 11/6/2021 | Wisconsin (9-4,6-3) | 52 | at | Rutgers | 3 | |||
| 11/13/2021 | Rutgers | 38 | at | Indiana (2-10,0-9) | 3 | |||
| 11/20/2021 | Rutgers | 0 | at | Penn State (7-6,4-5) | 28 | |||
| 11/27/2021 | Maryland (7-6,3-6) | 40 | at | Rutgers | 16 | |||
| 12/31/2021 | Wake Forest (11-3) | 38 | vs | Rutgers | 10 | Gator Bowl - Jacksonville FL | ACC |
| vs Rutgers | vs Other Opponents | Rutgers compared to OOs | |
| Record: | 8-5 | 83-68 | |
| Points Scored: | 25.62 | 27.46 | 1.84 |
| Points Allowed: | 19.69 | 25.72 | -6.03 |
| Margin: | 5.93 | 1.74 | -4.19 |
| Total Points: | 45.31 | 53.18 | -7.87 |