| 9/3/2021 | Chapman | 35 | at | Pacific | 23 | SCIAC | ||
| Carnegie Mellon | 10 | at | Whitworth | 13 | TPAC | |||
| 9/4/2021 | Redlands | 24 | at | George Fox | 14 | SCIAC | ||
| Puget Sound | 35 | at | Willamette | 48 | ||||
| 9/11/2021 | Pacific Lutheran | 28 | at | Cal Lutheran | 42 | @ SCIAC | ||
| Lewis & Clark | 10 | at | Claremont-Mudd-Scripps | 34 | @ SCIAC | |||
| Simon Fraser | 20 | at | Linfield | 56 | GNWAC (D2) | |||
| Puget Sound | 10 | at | Redlands | 60 | @ SCIAC | |||
| Lincoln CA | 29 | at | Whitworth | 31 | None (Unk?) | |||
| 9/18/2021 | George Fox | 21 | at | Chapman | 23 | @ SCIAC | ||
| Whitworth | 31 | at | Claremont-Mudd-Scripps | 15 | @ SCIAC | |||
| Whittier | 14 | at | Lewis & Clark | 66 | SCIAC | |||
| La Verne | 12 | at | Pacific Lutheran | 22 | SCIAC | |||
| Pacific | 38 | at | Pomona-Pitzer | 35 | @ SCIAC | |||
| Cal Lutheran | 25 | at | Puget Sound | 21 | SCIAC | |||
| Linfield | 51 | at | Redlands | 10 | @ SCIAC | |||
| Lincoln CA | 34 | at | Willamette | 9 | None (Unk?) | |||
| 9/25/2021 | Willamette | 8 | at | Pomona-Pitzer | 44 | @ SCIAC | ||
| 10/2/2021 | George Fox | 27 | at | Pacific Lutheran | 14 | |||
| Linfield | 56 | at | Puget Sound | 7 | ||||
| Lewis & Clark | 17 | at | Whitworth | 35 | ||||
| Pacific | 49 | at | Willamette | 19 | ||||
| 10/9/2021 | Willamette | 14 | at | George Fox | 44 | |||
| Pacific Lutheran | 38 | at | Lewis & Clark | 37 | ||||
| Whitworth | 7 | at | Linfield | 42 | ||||
| Puget Sound | 6 | at | Pacific | 69 | ||||
| 10/16/2021 | Pacific | 23 | at | Linfield | 52 | |||
| George Fox | 49 | at | Puget Sound | 28 | ||||
| Pacific Lutheran | 17 | at | Whitworth | 31 | ||||
| Lewis & Clark | 43 | at | Willamette | 41 | ||||
| 10/23/2021 | Pacific | 14 | at | George Fox | 21 | |||
| Puget Sound | 29 | at | Lewis & Clark | 46 | ||||
| Linfield | 52 | at | Pacific Lutheran | 7 | ||||
| Willamette | 7 | at | Whitworth | 66 | ||||
| 10/30/2021 | George Fox | 7 | at | Linfield | 38 | |||
| Lewis & Clark | 19 | at | Pacific | 42 | ||||
| Whitworth | 68 | at | Puget Sound | 14 | ||||
| Pacific Lutheran | 24 | at | Willamette | 0 | ||||
| 11/6/2021 | George Fox | 40 | at | Lewis & Clark | 9 | |||
| Puget Sound | 0 | at | Pacific Lutheran | 33 | ||||
| Pacific | 14 | at | Whitworth | 7 | ||||
| Linfield | 77 | at | Willamette | 7 | ||||
| 11/13/2021 | Whitworth | 10 | at | George Fox | 16 | |||
| Lewis & Clark | 17 | at | Linfield | 51 | ||||
| Pacific Lutheran | 17 | at | Pacific | 20 | ||||
| Willamette | 34 | at | Puget Sound | 62 | ||||
| 11/20/2021 | Redlands | 10 | at | Linfield | 44 | SCIAC | ||
| 11/27/2021 | Linfield | 31 | at | St John's MN | 28 | @ MIA | ||
| 12/4/2021 | Linfield | 24 | at | Mary Hardin-Baylor | 49 | @ ASWC |