9/3/2015 | Notre Dame OH | 44 | at | Charleston WV | 56 | | | |
| West Virginia State | 59 | at | Fairmont State | 34 | | | |
9/5/2015 | Glenville State | 49 | at | Urbana | 0 | | | |
| Tusculum | 47 | at | Virginia-Wise | 28 | | | SAC |
| Concord | 28 | at | West Liberty | 29 | | | |
| Shepherd | 43 | at | West Virginia Wesleyan | 0 | | | |
9/10/2015 | West Virginia Wesleyan | 48 | at | Glenville State | 64 | | | |
9/12/2015 | Fairmont State | 10 | at | Concord | 27 | | | |
| Virginia-Wise | 0 | at | Notre Dame OH | 42 | | | |
| Charleston WV | 25 | at | Shepherd | 45 | | | |
| McKendree | 50 | at | West Liberty | 27 | | | GLV |
| Urbana | 30 | at | West Virginia State | 23 | | | |
9/17/2015 | West Liberty | 30 | at | Fairmont State | 36 | | | |
9/19/2015 | Glenville State | 30 | at | Charleston WV | 31 | | | |
| Notre Dame OH | 24 | at | Robert Morris | 35 | | | @ NE (1AA) |
| Concord | 23 | at | Urbana | 7 | | | |
| Shepherd | 41 | at | Virginia-Wise | 0 | | | |
| West Virginia State | 52 | at | West Virginia Wesleyan | 31 | | | |
9/24/2015 | Urbana | 12 | at | West Liberty | 28 | | | |
9/26/2015 | West Virginia Wesleyan | 17 | at | Concord | 59 | | | |
| Virginia-Wise | 21 | at | Glenville State | 37 | | | |
| Notre Dame OH | 14 | at | Shepherd | 43 | | | |
| Charleston WV | 34 | at | West Virginia State | 13 | | | |
10/1/2015 | Concord | 21 | at | Charleston WV | 29 | | | |
10/3/2015 | Glenville State | 38 | at | Notre Dame OH | 30 | | | |
| Fairmont State | 6 | at | Urbana | 0 | | | |
| West Virginia State | 52 | at | Virginia-Wise | 45 | | | |
| West Liberty | 38 | at | West Virginia Wesleyan | 31 | | | |
10/8/2015 | West Virginia Wesleyan | 27 | at | Fairmont State | 31 | | | |
10/10/2015 | Virginia-Wise | 21 | at | Concord | 63 | | | |
| Shepherd | 48 | at | Glenville State | 31 | | | |
| Urbana | 33 | at | Lake Erie | 30 | | | @ GLIAC |
| Charleston WV | 42 | at | West Liberty | 37 | | | |
| Notre Dame OH | 29 | at | West Virginia State | 32 | | | |
10/15/2015 | Glenville State | 48 | at | Alderson-Broaddus | 30 | | | @ D2Ind |
10/17/2015 | Fairmont State | 31 | at | Charleston WV | 38 | | | |
| Concord | 21 | at | Notre Dame OH | 23 | | | |
| West Virginia State | 17 | at | Shepherd | 46 | | | |
| West Liberty | 30 | at | Virginia-Wise | 6 | | | |
| Urbana | 7 | at | West Virginia Wesleyan | 34 | | | |
10/22/2015 | Notre Dame OH | 59 | at | West Liberty | 51 | | | |
10/24/2015 | Shepherd | 35 | at | Concord | 28 | | | |
| Virginia-Wise | 32 | at | Fairmont State | 41 | | | |
| Charleston WV | 37 | at | Urbana | 12 | | | |
| Glenville State | 21 | at | West Virginia State | 24 | | | |
10/29/2015 | West Virginia Wesleyan | 21 | at | Charleston WV | 65 | | | |
10/31/2015 | Concord | 25 | at | Glenville State | 30 | | | |
| Fairmont State | 33 | at | Notre Dame OH | 24 | | | |
| West Liberty | 10 | at | Shepherd | 44 | | | |
| West Virginia State | 21 | at | UNC Pembroke | 45 | | | @ D2Ind |
| Urbana | 19 | at | Virginia-Wise | 24 | | | |
11/5/2015 | Shepherd | 41 | at | Fairmont State | 14 | | | |
| Glenville State | 41 | at | West Liberty | 14 | | | |
11/7/2015 | Alderson-Broaddus | 21 | at | Charleston WV | 56 | | | D2Ind |
| West Virginia State | 7 | at | Concord | 52 | | | |
| Notre Dame OH | 47 | at | Urbana | 30 | | | |
| Virginia-Wise | 21 | at | West Virginia Wesleyan | 47 | | | |
11/12/2015 | Fairmont State | 28 | at | Glenville State | 24 | | | |
| Charleston WV | 59 | at | Virginia-Wise | 7 | | | |
11/14/2015 | West Virginia Wesleyan | 20 | at | Notre Dame OH | 60 | | | |
| Urbana | 20 | at | Shepherd | 52 | | | |
| West Liberty | 42 | at | West Virginia State | 36 | | | |
11/21/2015 | Indiana PA | 47 | at | Charleston WV | 21 | | NCAA D2 Championship - First Round | PSAC |
11/28/2015 | Indiana PA | 13 | at | Shepherd | 17 | | NCAA D2 Championship - Second Round | PSAC |
12/5/2015 | Slippery Rock | 16 | at | Shepherd | 28 | | NCAA D2 Quarterfinal | PSAC |
12/12/2015 | Grand Valley State | 32 | at | Shepherd | 34 | | NCAA D2 Semifinal | GLIAC |
12/19/2015 | Northwest Missouri State | 34 | vs | Shepherd | 7 | | D2 Championship (Kamsas City KS) | vs MAIAA |