| 9/3/2015 | Panhandle State | 31 | at | Angelo State | 52 | | | D2Ind |
| New Mexico Highlands | 10 | at | Eastern New Mexico | 40 | | | RMAC |
| Adams State | 17 | at | Texas A&M-Commerce | 48 | | | RMAC |
| Azusa Pacific | 27 | at | West Texas A&M | 24 | | | GNWAC |
| 9/5/2015 | Texas A&M-Kingsville | 16 | at | Incarnate Word | 18 | | | @ SLC (1AA) |
| Truman State | 3 | at | Midwestern State | 31 | | | GLV |
| 9/12/2015 | Eastern New Mexico | 44 | at | Adams State | 30 | | | @ RMAC |
| Midwestern State | 16 | at | Colorado Mesa | 13 | OT | | @ RMAC |
| Delta State | 51 | at | Texas A&M-Commerce | 44 | | | GSC |
| Missouri S&T | 20 | at | Texas A&M-Kingsville | 38 | | | GLV |
| Findlay | 35 | at | Tarleton State | 34 | | | GLIAC |
| Colorado State-Pueblo | 30 | at | West Texas A&M | 31 | | | RMAC |
| Angelo State | 48 | at | Western State | 20 | | | @ RMAC |
| 9/19/2015 | Bacone | 0 | vs | Angelo State | 56 | | Arlington TX | vs CSFL (NAIA) |
| Midwestern State | 28 | vs | Eastern New Mexico | 24 | | Arlington TX | |
| Texas A&M-Commerce | 37 | at | Texas A&M-Kingsville | 17 | | | |
| West Texas A&M | 52 | vs | Tarleton State | 37 | | Arlington TX | |
| 9/26/2015 | Tarleton State | 46 | at | Midwestern State | 63 | | | |
| Eastern New Mexico | 31 | at | Texas A&M-Commerce | 42 | | | |
| West Alabama | 31 | at | Texas A&M-Kingsville | 22 | | | GSC |
| Angelo State | 35 | at | West Texas A&M | 17 | | | |
| 10/3/2015 | Midwestern State | 29 | at | Angelo State | 20 | | | |
| Texas A&M-Kingsville | 31 | at | Eastern New Mexico | 56 | | | |
| Texas A&M-Commerce | 63 | at | Tarleton State | 0 | | | |
| 10/10/2015 | Eastern New Mexico | 77 | at | Bacone | 14 | | | @ CSFL (NAIA) |
| West Texas A&M | 17 | at | Midwestern State | 24 | | | |
| Angelo State | 35 | at | Texas A&M-Commerce | 38 | | | |
| Tarleton State | 38 | at | Texas A&M-Kingsville | 34 | | | |
| 10/17/2015 | Texas A&M-Kingsville | 34 | at | Angelo State | 39 | | | |
| Humboldt State | 10 | at | Midwestern State | 35 | | | GNWAC |
| Eastern New Mexico | 49 | at | Tarleton State | 44 | | | |
| Texas A&M-Commerce | 38 | at | West Texas A&M | 20 | | | |
| 10/24/2015 | Angelo State | 28 | at | Eastern New Mexico | 46 | | | |
| Midwestern State | 14 | at | Texas A&M-Commerce | 27 | | | |
| West Texas A&M | 24 | at | Texas A&M-Kingsville | 14 | | | |
| Panhandle State | 47 | at | Tarleton State | 84 | | | D2Ind |
| 10/31/2015 | Tarleton State | 24 | at | Angelo State | 57 | | | |
| Texas A&M-Kingsville | 41 | at | Midwestern State | 49 | | | |
| Texas A&M-Commerce | 24 | at | Sam Houston | 38 | | | @ SLC (1AA) |
| Eastern New Mexico | 42 | at | West Texas A&M | 52 | | | |
| 11/7/2015 | Eastern New Mexico | 21 | at | Midwestern State | 26 | | | |
| West Texas A&M | 28 | at | Panhandle State | 21 | | | @ D2Ind |
| Angelo State | 35 | at | Texas A&M-Commerce | 36 | | | |
| Texas A&M-Kingsville | 43 | at | Tarleton State | 25 | | | |
| 11/14/2015 | Angelo State | 63 | at | Eastern New Mexico | 20 | | | |
| Midwestern State | 37 | at | Texas A&M-Commerce | 33 | | | |
| Panhandle State | 47 | at | Tarleton State | 48 | | | D2Ind |
| Texas A&M-Kingsville | 45 | at | West Texas A&M | 51 | | | |
| 11/21/2015 | Texas A&M-Commerce | 30 | at | Ferris State | 48 | | NCAA D2 Championship - First Round | @ GLIAC |
| 11/28/2015 | Colorado State-Pueblo | 26 | at | Midwestern State | 17 | | NCAA D2 Championship - Second Round | RMAC |
| 12/5/2015 | Arkansas Tech | 51 | vs | Eastern New Mexico | 35 | | Copperas Cove TX | vs GAC |