| 9/5/2015 | Colorado Mesa | 43 | at | Dixie State (3-7) | 3 | at GNWAC | ||
| 9/12/2015 | Midwestern State (10-2) | 16 | at | Colorado Mesa | 13 | OT | LSC | |
| 9/19/2015 | Adams State (3-8,3-6) | 16 | at | Colorado Mesa | 55 | |||
| 9/26/2015 | Colorado Mesa | 23 | at | Chadron State (5-6,4-5) | 13 | |||
| 10/3/2015 | Black Hills State (0-11,0-9) | 7 | at | Colorado Mesa | 48 | |||
| 10/10/2015 | Colorado Mesa | 31 | at | New Mexico Highlands (2-9,2-7) | 6 | |||
| 10/17/2015 | Western New Mexico (4-7,3-6) | 26 | at | Colorado Mesa | 52 | |||
| 10/24/2015 | Colorado Mesa | 21 | at | Fort Lewis (7-4,6-3) | 13 | |||
| 10/31/2015 | Colorado Mines (8-3,6-3) | 17 | at | Colorado Mesa | 31 | |||
| 11/7/2015 | Colorado Mesa | 20 | at | Colorado State-Pueblo (12-2,9-0) | 51 | |||
| 11/14/2015 | Colorado Mesa | 31 | at | Western State (4-7,4-5) | 28 | OT |
| vs Colorado Mesa | vs Other Opponents | Colorado Mesa compared to OOs | |
| Record: | 2-9 | 56-57 | |
| Points Scored: | 17.82 | 30.01 | 12.19 |
| Points Allowed: | 33.45 | 31.29 | 2.16 |
| Margin: | -15.63 | -1.28 | 14.35 |
| Total Points: | 51.27 | 61.30 | -10.03 |