| 9/1/2012 | Louisiana College | 34 | at | Webber International (4-6) | 16 | at NAIAInd | ||
| 9/8/2012 | Louisiana College | 24 | at | Belhaven (6-5) | 13 | at MSC | ||
| 9/22/2012 | Wesley (10-2) | 25 | at | Louisiana College | 22 | D3Ind | ||
| 9/29/2012 | Howard Payne (1-9,1-6) | 6 | at | Louisiana College | 38 | |||
| 10/6/2012 | Louisiana College | 29 | at | East Texas Baptist (3-7,2-5) | 17 | |||
| 10/13/2012 | Mary Hardin-Baylor (13-1,8-0) | 30 | at | Louisiana College | 3 | |||
| 10/20/2012 | Louisiana College | 41 | at | Sul Ross State (5-5,4-3) | 24 | |||
| 10/27/2012 | Texas Lutheran (4-6,2-5) | 37 | at | Louisiana College | 44 | OT | ||
| 11/3/2012 | Louisiana College | 70 | at | Mississippi College (2-8,1-6) | 28 | |||
| 11/10/2012 | Hardin-Simmons (6-4,5-2) | 37 | at | Louisiana College | 45 | |||
| 11/17/2012 | Louisiana College | 20 | at | Mary Hardin-Baylor (13-1,8-0) | 59 | Div 3 Playoffs 1st Round |
| vs Louisiana College | vs Other Opponents | Louisiana College compared to OOs | |
| Record: | 3-8 | 62-46 | |
| Points Scored: | 26.55 | 36.63 | 10.08 |
| Points Allowed: | 33.64 | 29.44 | 4.20 |
| Margin: | -7.09 | 7.19 | 14.28 |
| Total Points: | 60.19 | 66.07 | -5.88 |