9/1/2012 | Texas Lutheran | 38 | at | Austin | 16 | | | @ D3Ind |
| Wesley | 34 | at | East Texas Baptist | 14 | | | vs D3Ind |
| Willamette | 58 | at | Hardin-Simmons | 34 | | | vs NWC |
| Mississippi College | 17 | at | Millsaps | 23 | | | @ SCAC |
| Western New Mexico | 54 | at | Sul Ross State | 44 | | | vs RMAC (D2) |
| Howard Payne | 7 | at | Trinity TX | 56 | | | @ D3Ind |
| Louisiana College | 34 | at | Webber International | 16 | | | @ NAIAInd (NAIA) |
9/8/2012 | East Texas Baptist | 17 | at | Austin | 7 | | | @ D3Ind |
| Louisiana College | 24 | at | Belhaven | 13 | | | @ MSC (NAIA) |
| Sul Ross State | 35 | at | Eastern New Mexico | 38 | | | @ LSC (D2) |
| Southwestern Assemblies of God | 27 | at | Howard Payne | 17 | | | vs CSFL (NAIA) |
| Hardin-Simmons | 35 | at | Linfield | 49 | | | @ NWC |
| Kean | 7 | at | Mary Hardin-Baylor | 34 | | | vs NJAC |
| Webber International | 24 | at | Mississippi College | 31 | | | vs NAIAInd (NAIA) |
| Trinity TX | 31 | at | Texas Lutheran | 7 | | | vs D3Ind |
9/14/2012 | East Texas Baptist | 24 | at | Willamette | 38 | | | @ NWC |
9/15/2012 | Texas College | 21 | at | Hardin-Simmons | 57 | | | vs CSFL (NAIA) |
| Trinity TX | 35 | at | Sul Ross State | 62 | | | vs D3Ind |
| Howard Payne | 23 | at | Wayland Baptist | 27 | | | @ CSFL (NAIA) |
| Mary Hardin-Baylor | 32 | at | Wesley | 25 | | | @ D3Ind |
| Mississippi College | 3 | at | West Alabama | 41 | | | @ GSC (D2) |
9/22/2012 | Wesley | 25 | at | Louisiana College | 22 | | | vs D3Ind |
| Texas Lutheran | 43 | at | Southwestern Assemblies of God | 35 | | | @ CSFL (NAIA) |
| Mary Hardin-Baylor | 49 | at | Trinity TX | 28 | | | @ D3Ind |
9/29/2012 | Mississippi College | 0 | at | Hardin-Simmons | 31 | | | |
| Howard Payne | 6 | at | Louisiana College | 38 | | | |
| Mary Hardin-Baylor | 76 | at | Sul Ross State | 28 | | | |
| East Texas Baptist | 28 | at | Texas Lutheran | 34 | | | |
10/6/2012 | Louisiana College | 29 | at | East Texas Baptist | 17 | | | |
| Hardin-Simmons | 56 | at | Howard Payne | 10 | | | |
| Texas Lutheran | 31 | at | Mary Hardin-Baylor | 49 | | | |
| Sul Ross State | 75 | at | Mississippi College | 42 | | | |
10/13/2012 | East Texas Baptist | 22 | at | Hardin-Simmons | 42 | | | |
| Mississippi College | 14 | at | Howard Payne | 27 | | | |
| Mary Hardin-Baylor | 30 | at | Louisiana College | 3 | | | |
| Sul Ross State | 70 | at | Texas Lutheran | 65 | | | |
10/20/2012 | Howard Payne | 28 | at | East Texas Baptist | 52 | | | |
| Hardin-Simmons | 32 | at | Mary Hardin-Baylor | 45 | | | |
| Louisiana College | 41 | at | Sul Ross State | 24 | | | |
| Mississippi College | 24 | at | Texas Lutheran | 21 | | | |
10/27/2012 | Sul Ross State | 42 | at | Hardin-Simmons | 86 | | | |
| Mary Hardin-Baylor | 68 | at | Howard Payne | 6 | | | |
| Texas Lutheran | 37 | at | Louisiana College | 44 | OT | | |
| East Texas Baptist | 34 | at | Mississippi College | 24 | | | |
11/3/2012 | Mary Hardin-Baylor | 54 | at | East Texas Baptist | 20 | | | |
| Louisiana College | 70 | at | Mississippi College | 28 | | | |
| Howard Payne | 17 | at | Sul Ross State | 58 | | | |
| Hardin-Simmons | 65 | at | Texas Lutheran | 58 | 2OT | | |
11/10/2012 | Sul Ross State | 50 | at | East Texas Baptist | 37 | | | |
| Texas Lutheran | 47 | at | Howard Payne | 6 | | | |
| Hardin-Simmons | 37 | at | Louisiana College | 45 | | | |
| Mississippi College | 0 | at | Mary Hardin-Baylor | 59 | | | |
11/17/2012 | Louisiana College | 20 | at | Mary Hardin-Baylor | 59 | | Div 3 Playoffs 1st Round | |
11/24/2012 | Franklin | 17 | at | Mary Hardin-Baylor | 63 | | D3 Playoffs Round 2 | vs HCA |
12/1/2012 | Wesley | 20 | at | Mary Hardin-Baylor | 32 | | D3 Quarterfinals | vs D3Ind |
12/8/2012 | Mary Hardin-Baylor | 35 | at | Mount Union | 48 | | D3 Semifinals | @ OAC |