| 9/1/2012 | Murray State (5-6) | 3 | at | Florida State | 69 | OVC (1AA) | ||
| 9/8/2012 | Savannah State (1-10) | 0 | at | Florida State | 55 | MEAC (1AA) | ||
| 9/15/2012 | Wake Forest (5-7,3-5) | 0 | at | Florida State | 52 | |||
| 9/22/2012 | Clemson (11-2,7-1) | 37 | at | Florida State | 49 | |||
| 9/29/2012 | Florida State | 30 | at | South Florida (3-9) | 17 | at BigE | ||
| 10/6/2012 | Florida State | 16 | at | North Carolina State (7-6,4-4) | 17 | |||
| 10/13/2012 | Boston College (2-10,1-7) | 7 | at | Florida State | 51 | |||
| 10/20/2012 | Florida State | 33 | at | Miami-Florida (7-5,5-3) | 20 | |||
| 10/27/2012 | Duke (6-7,3-5) | 7 | at | Florida State | 48 | |||
| 11/8/2012 | Florida State | 28 | at | Virginia Tech (7-6,4-4) | 22 | |||
| 11/17/2012 | Florida State | 41 | at | Maryland (4-8,2-6) | 14 | |||
| 11/24/2012 | Florida (11-2) | 37 | at | Florida State | 26 | SEC | ||
| 12/1/2012 | Florida State | 21 | vs | Georgia Tech (7-7,5-4) | 15 | ACC Championship | ||
| 1/1/2013 | Northern Illinois (12-2) | 10 | vs | Florida State | 31 | Discover Orange Bowl | MAC |
| vs Florida State | vs Other Opponents | Florida State compared to OOs | |
| Record: | 2-12 | 86-75 | |
| Points Scored: | 14.71 | 29.11 | 14.40 |
| Points Allowed: | 39.29 | 27.58 | 11.71 |
| Margin: | -24.58 | 1.53 | 26.11 |
| Total Points: | 54.00 | 56.69 | -2.69 |