| 9/1/2012 | Panhandle State | 14 | at | Missouri S&T (10-1) | 55 | at GLV | ||
| 9/8/2012 | Lindenwood-Belleville (4-6) | 23 | at | Panhandle State | 30 | OT | NAIAInd (NAIA) | |
| 9/29/2012 | McMurry (8-3,1-0) | 42 | at | Panhandle State | 33 | |||
| 10/6/2012 | Panhandle State | 30 | at | Texas College (3-8) | 9 | at CSFL | ||
| 10/13/2012 | Panhandle State | 7 | at | Bacone (6-4) | 40 | at CSFL | ||
| 10/20/2012 | Panhandle State | 30 | at | Northwestern Oklahoma State (3-7) | 34 | at GAC | ||
| 10/27/2012 | Southwestern Assemblies of God (3-7) | 28 | at | Panhandle State | 27 | OT | CSFL (NAIA) | |
| 11/3/2012 | Wayland Baptist (2-7) | 14 | at | Panhandle State | 67 | CSFL (NAIA) | ||
| 11/10/2012 | Langston (6-4) | 27 | at | Panhandle State | 20 | CSFL (NAIA) |
| vs Panhandle State | vs Other Opponents | Panhandle State compared to OOs | |
| Record: | 6-3 | 39-44 | |
| Points Scored: | 30.22 | 23.08 | -7.14 |
| Points Allowed: | 28.67 | 28.08 | 0.59 |
| Margin: | 1.55 | -5.00 | -6.55 |
| Total Points: | 58.89 | 51.16 | 7.73 |