| 9/4/2010 | Lawrence Vikings 24 @ St Scholastica 31 | |
| 9/11/2010 | Eureka Red Devils 21 @ St Scholastica 38 | † |
| 9/18/2010 | St Scholastica 7 @ Concordia IL Cougars 49 | |
| 9/25/2010 | St Scholastica 7 @ Martin Luther Knights 21 | † |
| 10/2/2010 | Crown Storm 21 @ St Scholastica 41 | † |
| 10/9/2010 | Greenville Panthers 35 @ St Scholastica 7 | † |
| 10/23/2010 | St Scholastica 28 @ Minnesota-Morris Cougars 7 | † |
| 10/30/2010 | MacMurray Highlanders 18 vs St Scholastica 48 (Minneapolis MN) | † |
| 11/6/2010 | Northwestern MN Eagles 7 @ St Scholastica 10 | † |
| 11/13/2010 | St Scholastica 34 @ Westminster MO Blue Jays 28 | † |