| 9/4/2010 | Ill. Benedictine Eagles 42 @ Eureka 7 | |
| 9/11/2010 | Eureka 21 @ St Scholastica Saints 38 | † |
| 9/18/2010 | Eureka 0 @ Wisconsin-Stout Blue Devils 63 | |
| 9/25/2010 | Minnesota-Morris Cougars 47 @ Eureka 29 | † |
| 10/9/2010 | Eureka 14 @ Westminster MO Blue Jays 34 | † |
| 10/16/2010 | Eureka 14 @ Crown Storm 36 | † |
| 10/23/2010 | Northwestern MN Eagles 14 @ Eureka 40 | † |
| 10/30/2010 | Eureka 13 vs Martin Luther Knights 52 (Minneapolis MN) | † |
| 11/6/2010 | Eureka 27 @ Greenville Panthers 62 | † |
| 11/13/2010 | MacMurray Highlanders 21 @ Eureka 42 | † |