| 9/4/2010 | Minnesota-Morris Cougars 49 @ MacMurray 19 | † |
| 9/11/2010 | Aurora Spartans 45 @ MacMurray 12 | |
| 9/18/2010 | MacMurray 7 @ North Park Vikings 70 | |
| 9/25/2010 | Bethany KS Terrible Swedes 38 @ MacMurray 7 | |
| 10/2/2010 | MacMurray 34 @ Northwestern MN Eagles 37 | † |
| 10/16/2010 | MacMurray 7 @ Greenville Panthers 50 | † |
| 10/23/2010 | Crown Storm 44 @ MacMurray 28 | † |
| 10/30/2010 | MacMurray 18 vs St Scholastica Saints 48 (Minneapolis MN) | † |
| 11/6/2010 | Westminster MO Blue Jays 39 @ MacMurray 7 | † |
| 11/13/2010 | MacMurray 21 @ Eureka Red Devils 42 | † |