| 9/6/2009 | Grambling 34 vs S Carolina St 31 (Orlando FL) | |
| 9/12/2009 | S Carolina St 24 @ Bethune-Cookman 3 | † |
| 9/26/2009 | Winston-Salem St 10 @ S Carolina St 27 | † |
| 10/3/2009 | S Carolina St 14 @ South Carolina 38 | |
| 10/10/2009 | S Carolina St 37 @ Norfolk St 10 | † |
| 10/17/2009 | Florida A&M 20 @ S Carolina St 35 | † |
| 10/24/2009 | S Carolina St 21 @ Hampton 9 | † |
| 10/31/2009 | Delaware St 10 @ S Carolina St 52 | † |
| 11/7/2009 | S Carolina St 43 @ Howard 13 | † |
| 11/14/2009 | Morgan St 13 @ S Carolina St 37 | † |
| 11/21/2009 | NC A&T 10 @ S Carolina St 28 | † |
| 11/28/2009 | S Carolina St 13 @ Appalachian St 20 (FCS Playoff round 1) |