| 9/5/2009 | Northwestern St 7 @ Houston 55 | |
| 9/12/2009 | Houston 45 @ Oklahoma St 35 | |
| 9/26/2009 | Texas Tech 28 @ Houston 29 | |
| 10/3/2009 | Houston 41 @ UTEP 58 | † |
| 10/10/2009 | Houston 31 @ Mississippi St 24 | |
| 10/17/2009 | Houston 44 @ Tulane 16 | † |
| 10/24/2009 | SMU 15 @ Houston 38 | † |
| 10/31/2009 | Southern Miss 43 @ Houston 50 | † |
| 11/7/2009 | Houston 46 @ Tulsa 45 | † |
| 11/14/2009 | Houston 32 @ UCF 37 | † |
| 11/21/2009 | Memphis 14 @ Houston 55 | † |
| 11/28/2009 | Rice 14 @ Houston 73 | † |
| 12/5/2009 | Houston 32 @ East Carolina 38 (CUSA CG) | † |
| 12/31/2009 | Houston 20 vs Air Force 47 (Armed Forces Bowl) |