| 9/5/2009 | Appalachian St 24 @ East Carolina 29 | |
| 9/12/2009 | East Carolina 20 @ West Virginia 35 | |
| 9/19/2009 | East Carolina 17 @ North Carolina 31 | |
| 9/26/2009 | UCF 14 @ East Carolina 19 | † |
| 10/3/2009 | East Carolina 21 @ Marshall 17 | † |
| 10/10/2009 | East Carolina 21 @ SMU 28 | † |
| 10/17/2009 | Rice 13 @ East Carolina 49 | † |
| 10/27/2009 | East Carolina 38 @ Memphis 19 | † |
| 11/5/2009 | Virginia Tech 16 @ East Carolina 3 | |
| 11/15/2009 | East Carolina 44 @ Tulsa 17 | † |
| 11/21/2009 | UAB 21 @ East Carolina 37 | † |
| 11/28/2009 | Southern Miss 20 @ East Carolina 25 | † |
| 12/5/2009 | Houston 32 @ East Carolina 38 (CUSA CG) | † |
| 1/2/2010 | Arkansas 20 vs East Carolina 17 1OT (Liberty Bowl) |