| 9/2/2006 | Eastern Illinois | 17 | @ | Illinois | 42 | ||||
| 9/9/2006 | Indiana St | 21 | @ | Eastern Illinois | 31 | ||||
| 9/16/2006 | Eastern Illinois | 30 | @ | Illinois St | 44 | ||||
| 9/23/2006 | Eastern Illinois | 24 | @ | Samford | 13 | OVC | |||
| 9/30/2006 | Eastern Illinois | 9 | @ | Hawaii | 44 | ||||
| 10/7/2006 | SE Missouri St | 0 | @ | Eastern Illinois | 21 | OVC | |||
| 10/14/2006 | Eastern Illinois | 28 | @ | Eastern Kentucky | 21 | OVC | |||
| 10/21/2006 | Murray St | 10 | @ | Eastern Illinois | 20 | OVC | |||
| 10/28/2006 | Eastern Illinois | 9 | @ | Tennessee-Martin | 15 | OT | OVC | ||
| 11/4/2006 | Tennessee St | 3 | @ | Eastern Illinois | 29 | OVC | |||
| 11/11/2006 | Eastern Illinois | 38 | @ | Tennessee Tech | 14 | OVC | |||
| 11/18/2006 | Jacksonville St | 24 | @ | Eastern Illinois | 28 | OVC | |||
| 11/25/2006 | Illinois St | 24 | @ | Eastern Illinois | 13 | 1-AA Playoffs |