| 9/2/2006 | Illinois St | 23 | @ | Kansas St | 24 | ||||
| 9/9/2006 | Central Arkansas | 3 | @ | Illinois St | 10 | ||||
| 9/16/2006 | Eastern Illinois | 30 | @ | Illinois St | 44 | ||||
| 9/23/2006 | Illinois St | 35 | @ | Murray St | 14 | ||||
| 10/7/2006 | Illinois St | 28 | @ | Western Kentucky | 27 | GW | |||
| 10/14/2006 | Southern Illinois | 10 | @ | Illinois St | 37 | GW | |||
| 10/21/2006 | Illinois St | 27 | @ | Western Illinois | 14 | GW | |||
| 10/28/2006 | Youngstown St | 27 | @ | Illinois St | 13 | GW | |||
| 11/4/2006 | Missouri State | 14 | @ | Illinois St | 38 | GW | |||
| 11/11/2006 | Illinois St | 42 | @ | Indiana St | 20 | GW | |||
| 11/18/2006 | Illinois St | 27 | @ | Northern Iowa | 38 | GW | |||
| 11/25/2006 | Illinois St | 24 | @ | Eastern Illinois | 13 | 1-AA Playoffs | |||
| 12/2/2006 | Illinois St | 21 | @ | Youngstown St | 28 | GW | 1-AA Playoffs |