| 9/10/2022 | Kentucky Christian (3-8,3-7) | 33 | at | Pikeville | 54 | |||
| 9/17/2022 | Cumberland TN (3-7,2-7) | 37 | at | Pikeville | 47 | |||
| 9/24/2022 | Pikeville | 16 | at | Bethel TN (11-1,10-0) | 45 | |||
| 10/1/2022 | Pikeville | 26 | at | Bluefield (8-3,8-2) | 50 | |||
| 10/8/2022 | Georgetown KY (7-3,7-3) | 40 | at | Pikeville | 20 | |||
| 10/15/2022 | Pikeville | 24 | at | Cumberlands KY (5-5,5-5) | 17 | |||
| 10/22/2022 | Campbellsville (2-8,2-8) | 41 | at | Pikeville | 66 | |||
| 10/29/2022 | Pikeville | 28 | at | Thomas More (5-6,5-5) | 24 | |||
| 11/5/2022 | Lindsey Wilson (10-2,10-1) | 39 | at | Pikeville | 9 | |||
| 11/12/2022 | Pikeville | 36 | at | Faulkner (4-7,4-6) | 22 |
| vs Pikeville | vs Other Opponents | Pikeville compared to OOs | |
| Record: | 4-6 | 54-44 | |
| Points Scored: | 34.80 | 27.27 | -7.53 |
| Points Allowed: | 32.60 | 23.79 | 8.81 |
| Margin: | 2.20 | 3.48 | 1.28 |
| Total Points: | 67.40 | 51.06 | 16.34 |