| 9/3/2022 | Puget Sound (1-8,1-7) | 15 | at | Lewis & Clark | 41 | |||
| 9/17/2022 | Lewis & Clark | 44 | at | Whittier (0-9) | 13 | at SCIAC | ||
| 10/1/2022 | Whitworth (6-4,4-3) | 66 | at | Lewis & Clark | 28 | |||
| 10/8/2022 | Lewis & Clark | 21 | at | Pacific Lutheran (6-4,5-2) | 47 | |||
| 10/15/2022 | Willamette (2-8,0-7) | 17 | at | Lewis & Clark | 39 | |||
| 10/22/2022 | Lewis & Clark | 47 | at | Puget Sound (1-8,1-7) | 41 | OT | ||
| 10/29/2022 | Pacific (5-4,4-3) | 56 | at | Lewis & Clark | 41 | |||
| 11/5/2022 | Lewis & Clark | 20 | at | George Fox (8-2,5-2) | 41 | |||
| 11/12/2022 | Linfield (10-1,7-0) | 70 | at | Lewis & Clark | 7 |
| vs Lewis & Clark | vs Other Opponents | Lewis & Clark compared to OOs | |
| Record: | 5-4 | 34-42 | |
| Points Scored: | 40.67 | 22.62 | -18.05 |
| Points Allowed: | 32.00 | 29.66 | 2.34 |
| Margin: | 8.67 | -7.04 | -15.71 |
| Total Points: | 72.67 | 52.28 | 20.39 |