| 9/2/2022 | Whitworth | 17 | at | Carnegie Mellon | 35 | @ TPAC | ||
| 9/3/2022 | Pacific Lutheran | 9 | at | Bethel MN | 41 | @ MIA | ||
| Pacific | 21 | at | Chapman | 42 | @ SCIAC | |||
| Linfield | 41 | at | Huntingdon AL | 34 | @ USASC | |||
| Puget Sound | 15 | at | Lewis & Clark | 41 | ||||
| George Fox | 38 | at | Redlands | 31 | @ SCIAC | |||
| Pomona-Pitzer | 44 | at | Willamette | 21 | SCIAC | |||
| 9/10/2022 | George Fox | 42 | at | Howard Payne | 39 | @ ASWC | ||
| Eastern Oregon | 7 | at | Whitworth | 33 | Front (NAIA) | |||
| La Verne | 14 | at | Willamette | 26 | SCIAC | |||
| 9/17/2022 | Puget Sound | 27 | at | Cal Lutheran | 35 | @ SCIAC | ||
| Chapman | 28 | at | George Fox | 38 | SCIAC | |||
| Willamette | 31 | at | Hilbert | 20 | @ D3Ind | |||
| Pacific Lutheran | 41 | at | La Verne | 0 | @ SCIAC | |||
| Redlands | 3 | at | Linfield | 21 | SCIAC | |||
| Pomona-Pitzer | 20 | at | Pacific | 23 | OT | SCIAC | ||
| Lewis & Clark | 44 | at | Whittier | 13 | @ SCIAC | |||
| Claremont-Mudd-Scripps | 7 | at | Whitworth | 12 | SCIAC | |||
| 9/24/2022 | Cal Lutheran | 17 | at | Pacific Lutheran | 14 | SCIAC | ||
| 10/1/2022 | Pacific Lutheran | 13 | at | George Fox | 12 | |||
| Whitworth | 66 | at | Lewis & Clark | 28 | ||||
| Puget Sound | 2 | at | Linfield | 72 | ||||
| Willamette | 0 | at | Pacific | 35 | ||||
| 10/8/2022 | Lewis & Clark | 21 | at | Pacific Lutheran | 47 | |||
| Pacific | 42 | at | Puget Sound | 21 | ||||
| Linfield | 35 | at | Whitworth | 17 | ||||
| George Fox | 27 | at | Willamette | 10 | ||||
| 10/15/2022 | Puget Sound | 7 | at | George Fox | 51 | |||
| Willamette | 17 | at | Lewis & Clark | 39 | ||||
| Whitworth | 7 | at | Pacific Lutheran | 28 | ||||
| Linfield | 42 | at | Pacific | 21 | ||||
| 10/22/2022 | Pacific Lutheran | 0 | at | Linfield | 45 | |||
| George Fox | 21 | at | Pacific | 7 | ||||
| Lewis & Clark | 47 | at | Puget Sound | 41 | OT | |||
| Whitworth | 42 | at | Willamette | 14 | ||||
| 10/29/2022 | Linfield | 37 | at | George Fox | 10 | |||
| Pacific | 56 | at | Lewis & Clark | 41 | ||||
| Willamette | 0 | at | Pacific Lutheran | 53 | ||||
| Puget Sound | 0 | at | Whitworth | 59 | ||||
| 11/5/2022 | Lewis & Clark | 20 | at | George Fox | 41 | |||
| Willamette | 0 | at | Linfield | 65 | ||||
| Whitworth | 28 | at | Pacific | 17 | ||||
| Pacific Lutheran | 35 | at | Puget Sound | 10 | ||||
| 11/12/2022 | Linfield | 70 | at | Lewis & Clark | 7 | |||
| Pacific | 18 | at | Pacific Lutheran | 7 | ||||
| George Fox | 28 | at | Whitworth | 14 | ||||
| Puget Sound | 26 | at | Willamette | 20 | ||||
| 11/19/2022 | Pomona-Pitzer | 24 | at | Linfield | 51 | D3 Championship Round 1 | SCIAC | |
| 11/26/2022 | Bethel MN | 30 | at | Linfield | 13 | D3 Playoffs Round 2 | MIA |