| 9/2/2021 | Union KY (2-7,2-7) | 33 | at | Campbellsville | 18 | |||
| 9/4/2021 | Union KY (2-7,2-7) | 33 | at | Campbellsville | 18 | |||
| 9/18/2021 | Campbellsville | 7 | at | Reinhardt (9-3,9-2) | 52 | |||
| 9/30/2021 | Thomas More (5-5,5-5) | 73 | at | Campbellsville | 28 | |||
| 10/9/2021 | Pikeville (4-5,4-5) | 28 | at | Campbellsville | 31 | |||
| 10/16/2021 | Cumberland TN (3-7,3-7) | 54 | at | Campbellsville | 32 | |||
| 10/23/2021 | Campbellsville | 27 | at | Cumberlands KY (6-4,6-4) | 52 | |||
| 10/30/2021 | Georgetown KY (8-2,8-2) | 42 | at | Campbellsville | 3 | |||
| 11/6/2021 | Campbellsville | 14 | at | Lindsey Wilson (12-1,11-0) | 77 | |||
| 11/13/2021 | Campbellsville | 21 | at | Bethel TN (7-4,7-3) | 46 |
| vs Campbellsville | vs Other Opponents | Campbellsville compared to OOs | |
| Record: | 9-1 | 47-44 | |
| Points Scored: | 49.00 | 28.60 | -20.40 |
| Points Allowed: | 19.90 | 23.30 | -3.40 |
| Margin: | 29.10 | 5.30 | -23.80 |
| Total Points: | 68.90 | 51.90 | 17.00 |