| 8/31/2019 | Wofford (8-4) | 13 | at | South Carolina State | 28 | SoCon | ||
| 9/7/2019 | Lane (4-6) | 0 | at | South Carolina State | 34 | SIAC (D2) | ||
| 9/14/2019 | South Carolina State | 16 | at | South Florida (4-8) | 55 | at AAC | ||
| 10/5/2019 | South Carolina State | 38 | at | Delaware State (2-10,1-7) | 24 | |||
| 10/12/2019 | Florida A&M (9-2,7-1) | 42 | at | South Carolina State | 38 | |||
| 10/19/2019 | Morgan State (3-9,2-6) | 10 | at | South Carolina State | 24 | |||
| 10/26/2019 | South Carolina State | 27 | at | Bethune-Cookman (7-4,5-3) | 19 | |||
| 11/2/2019 | North Carolina A&T (9-3,6-2) | 22 | at | South Carolina State | 20 | |||
| 11/9/2019 | Howard (2-10,2-6) | 21 | at | South Carolina State | 62 | |||
| 11/16/2019 | South Carolina State | 24 | at | North Carolina Central (4-8,3-5) | 0 | |||
| 11/23/2019 | South Carolina State | 20 | at | Norfolk State (5-7,4-4) | 17 | OT |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 3-8 | 54-63 | |
| Points Scored: | 20.27 | 25.27 | 5.00 |
| Points Allowed: | 30.09 | 28.73 | 1.36 |
| Margin: | -9.82 | -3.46 | 6.36 |
| Total Points: | 50.36 | 54.00 | -3.64 |