| 9/5/2019 | West Florida | 13 | at | Carson-Newman | 20 | GSC | ||
| Tusculum | 10 | at | Delta State | 24 | @ GSC | |||
| Wingate | 42 | at | Johnson C Smith | 0 | @ CIAA | |||
| Newberry | 7 | at | North Greenville | 17 | @ GSC | |||
| 9/7/2019 | West Georgia | 37 | at | Catawba | 9 | GSC | ||
| St Augustine's | 7 | at | Lenoir-Rhyne | 68 | CIAA | |||
| Chowan | 22 | at | Virginia-Wise | 40 | CIAA | |||
| Mars Hill | 21 | at | VMI | 63 | @ SoCon (1AA) | |||
| Limestone | 18 | at | West Alabama | 35 | @ GSC | |||
| 9/14/2019 | Wingate | 34 | at | Fayetteville State | 24 | @ CIAA | ||
| West Georgia | 24 | at | Limestone | 14 | GSC | |||
| St Augustine's | 14 | at | Mars Hill | 46 | CIAA | |||
| Florida Tech | 30 | at | Newberry | 28 | GSC | |||
| Virginia-Wise | 14 | at | Tennessee Tech | 31 | @ OVC (1AA) | |||
| West Alabama | 47 | at | Tusculum | 14 | GSC | |||
| Lenoir-Rhyne | 28 | at | Virginia Union | 11 | @ CIAA | |||
| Catawba | 21 | at | Winston-Salem State | 14 | @ CIAA | |||
| 9/21/2019 | Newberry | 17 | at | Lenoir-Rhyne | 34 | |||
| Tusculum | 38 | at | Limestone | 10 | ||||
| Catawba | 14 | at | UNC Pembroke | 28 | @ D2Ind | |||
| Mars Hill | 21 | at | Virginia-Wise | 14 | ||||
| Carson-Newman | 28 | at | Wingate | 30 | ||||
| 9/28/2019 | Virginia-Wise | 7 | at | Carson-Newman | 42 | |||
| Wingate | 13 | at | Catawba | 10 | ||||
| Lenoir-Rhyne | 56 | at | Mars Hill | 28 | ||||
| Tusculum | 20 | at | Newberry | 30 | ||||
| Limestone | 41 | at | UNC Pembroke | 25 | @ D2Ind | |||
| 10/5/2019 | UNC Pembroke | 18 | at | Carson-Newman | 69 | D2Ind | ||
| Virginia-Wise | 6 | at | Lenoir-Rhyne | 63 | ||||
| Catawba | 24 | at | Limestone | 52 | ||||
| Mars Hill | 20 | at | Newberry | 19 | ||||
| Wingate | 28 | at | Tusculum | 21 | ||||
| 10/12/2019 | Catawba | 14 | at | Carson-Newman | 59 | |||
| Virginia-Wise | 7 | at | Newberry | 30 | ||||
| Lenoir-Rhyne | 38 | at | Tusculum | 14 | ||||
| Mars Hill | 29 | at | UNC Pembroke | 36 | @ D2Ind | |||
| Limestone | 3 | at | Wingate | 34 | ||||
| 10/19/2019 | Newberry | 44 | at | Catawba | 21 | |||
| Carson-Newman | 23 | at | Lenoir-Rhyne | 36 | ||||
| Limestone | 28 | at | Mars Hill | 35 | ||||
| Tusculum | 21 | at | Virginia-Wise | 19 | ||||
| UNC Pembroke | 38 | at | Wingate | 48 | D2Ind | |||
| 10/26/2019 | Newberry | 21 | at | Carson-Newman | 24 | |||
| Mars Hill | 55 | at | Catawba | 28 | ||||
| Lenoir-Rhyne | 28 | at | Limestone | 20 | ||||
| UNC Pembroke | 20 | at | Tusculum | 23 | D2Ind | |||
| Virginia-Wise | 13 | at | Wingate | 45 | ||||
| 11/2/2019 | Wingate | 13 | at | Lenoir-Rhyne | 20 | |||
| Carson-Newman | 48 | at | Mars Hill | 21 | ||||
| UNC Pembroke | 34 | at | Newberry | 37 | OT | D2Ind | ||
| Catawba | 14 | at | Tusculum | 32 | ||||
| Limestone | 27 | at | Virginia-Wise | 6 | ||||
| 11/9/2019 | UNC Pembroke | 31 | at | Lenoir-Rhyne | 45 | D2Ind | ||
| Carson-Newman | 42 | at | Limestone | 35 | ||||
| Mars Hill | 7 | at | Tusculum | 24 | ||||
| Catawba | 14 | at | Virginia-Wise | 21 | ||||
| Newberry | 28 | at | Wingate | 35 | ||||
| 11/16/2019 | Tusculum | 13 | at | Carson-Newman | 49 | |||
| Lenoir-Rhyne | 49 | at | Catawba | 3 | ||||
| Wingate | 64 | at | Mars Hill | 34 | ||||
| Limestone | 7 | at | Newberry | 14 | ||||
| Virginia-Wise | 7 | at | UNC Pembroke | 20 | @ D2Ind | |||
| 11/23/2019 | Carson-Newman | 17 | at | Bowie State | 9 | D2 Playoff round 1 | @ CIAA | |
| Miles | 7 | at | Lenoir-Rhyne | 26 | SIAC | |||
| West Florida | 38 | at | Wingate | 17 | D2 Playoff round 1 | GSC | ||
| 11/30/2019 | Carson-Newman | 21 | at | Lenoir-Rhyne | 49 | D2 Playoff Round 2 | ||
| 12/7/2019 | West Florida | 43 | at | Lenoir-Rhyne | 38 | D2 Quarterfinals | GSC |