| 9/5/2019 | Glenville State | 33 | at | Alderson-Broaddus | 21 | MtnE | ||
| Findlay | 23 | at | Ferris State | 24 | @ GLIAC | |||
| Lake Erie | 16 | at | Mercyhurst | 21 | @ PSAC | |||
| 9/7/2019 | Walsh | 3 | at | Duquesne | 44 | @ NE (1AA) | ||
| Michigan Tech | 29 | at | Hillsdale | 14 | GLIAC | |||
| Concordia MI | 17 | at | Kentucky Wesleyan | 14 | MSFA (NAIA) | |||
| Tiffin | 22 | at | Northwood | 19 | @ GLIAC | |||
| Ohio Dominican | 23 | at | Shepherd | 21 | @ PSAC | |||
| 9/14/2019 | Alderson-Broaddus | 16 | at | Chowan | 70 | @ CIAA | ||
| Northwood | 21 | at | Findlay | 31 | GLIAC | |||
| Hillsdale | 21 | at | Indianapolis | 48 | @ GLV | |||
| Quincy | 34 | at | Kentucky Wesleyan | 16 | GLV | |||
| Davenport | 13 | at | Lake Erie | 9 | GLIAC | |||
| Tiffin | 20 | at | Saginaw Valley State | 35 | @ GLIAC | |||
| Ohio Dominican | 21 | at | Valdosta State | 48 | @ GSC | |||
| Ashland | 34 | at | Walsh | 12 | GLIAC | |||
| 9/21/2019 | Alderson-Broaddus | 14 | at | Bowie State | 42 | @ CIAA | ||
| Lake Erie | 14 | at | Hillsdale | 34 | ||||
| Southwest Baptist | 20 | at | Kentucky Wesleyan | 13 | GLV | |||
| Findlay | 10 | at | Ohio Dominican | 21 | ||||
| Tiffin | 52 | at | Walsh | 0 | ||||
| 9/28/2019 | Alderson-Broaddus | 28 | at | Findlay | 75 | |||
| Walsh | 0 | at | Hillsdale | 30 | ||||
| Kentucky Wesleyan | 42 | at | Lake Erie | 49 | ||||
| Ohio Dominican | 31 | at | Tiffin | 41 | ||||
| 10/5/2019 | Ohio Dominican | 56 | at | Alderson-Broaddus | 10 | |||
| Kentucky Wesleyan | 13 | at | Findlay | 38 | ||||
| Concord | 14 | at | Hillsdale | 38 | MtnE | |||
| Walsh | 21 | at | Lake Erie | 6 | ||||
| Saint Anselm | 6 | at | Tiffin | 55 | NE10 | |||
| 10/12/2019 | Lake Erie | 38 | at | Alderson-Broaddus | 24 | |||
| Tiffin | 59 | at | Kentucky Wesleyan | 6 | ||||
| Hillsdale | 37 | at | Northwood | 30 | @ GLIAC | |||
| Findlay | 19 | at | Walsh | 10 | ||||
| 10/19/2019 | Hillsdale | 16 | at | Findlay | 41 | |||
| Ohio Dominican | 47 | at | Kentucky Wesleyan | 7 | ||||
| Lake Erie | 42 | at | Taylor | 20 | @ MSFA (NAIA) | |||
| Alderson-Broaddus | 7 | at | Tiffin | 45 | ||||
| West Liberty | 41 | at | Walsh | 38 | OT | MtnE | ||
| 10/26/2019 | Kentucky Wesleyan | 14 | at | Hillsdale | 41 | |||
| Tiffin | 63 | at | Lake Erie | 35 | ||||
| Findlay | 19 | at | Notre Dame OH | 24 | @ MtnE | |||
| Walsh | 0 | at | Ohio Dominican | 7 | ||||
| 11/2/2019 | Hillsdale | 56 | at | Alderson-Broaddus | 21 | |||
| Findlay | 61 | at | Lake Erie | 14 | ||||
| Kentucky Wesleyan | 24 | at | Walsh | 27 | ||||
| 11/9/2019 | Walsh | 17 | at | Alderson-Broaddus | 24 | |||
| Ashland | 18 | at | Findlay | 53 | GLIAC | |||
| Kentucky Wesleyan | 25 | at | Frostburg State | 35 | @ MtnE | |||
| Lake Erie | 10 | at | Ohio Dominican | 49 | ||||
| Hillsdale | 24 | at | Tiffin | 35 | ||||
| 11/16/2019 | Tiffin | 52 | at | Findlay | 45 | |||
| Ohio Dominican | 17 | at | Hillsdale | 7 | ||||
| Lake Erie | 6 | at | Indianapolis | 70 | @ GLV | |||
| Alderson-Broaddus | 30 | at | Kentucky Wesleyan | 41 | ||||
| Walsh | 42 | at | Missouri Baptist | 7 | @ MSFA (NAIA) | |||
| 11/23/2019 | Tiffin | 31 | at | Kutztown | 33 | D2 Playoff round 1 | @ PSAC | |
| 12/7/2019 | Ohio Dominican | 7 | vs | Truman State | 21 | Hobart IN | vs GLV |