| 9/7/2019 | Concord (1-10,1-9) | 10 | at | Notre Dame OH | 33 | | | |
| 9/12/2019 | Notre Dame OH | 43 | at | West Liberty (5-6,4-6) | 24 | | | |
| 9/21/2019 | Fairmont State (5-5,5-5) | 49 | at | Notre Dame OH | 61 | | | |
| 9/28/2019 | Notre Dame OH | 40 | at | Urbana (7-4,7-3) | 20 | | | |
| 10/5/2019 | West Virginia Wesleyan (1-10,1-9) | 6 | at | Notre Dame OH | 52 | | | |
| 10/12/2019 | Notre Dame OH | 63 | at | Charleston WV (8-3,7-3) | 53 | | | |
| 10/19/2019 | Wheeling Jesuit (1-10,1-9) | 13 | at | Notre Dame OH | 51 | | | |
| 10/26/2019 | Findlay (7-4) | 19 | at | Notre Dame OH | 24 | | | GMAC |
| 11/2/2019 | Notre Dame OH | 35 | at | Frostburg State (8-3,7-3) | 13 | | | |
| 11/9/2019 | Glenville State (7-4,6-4) | 23 | at | Notre Dame OH | 20 | OT | | |
| 11/16/2019 | Notre Dame OH | 31 | at | West Virginia State (7-4,7-3) | 14 | | | |
| 11/23/2019 | West Chester (9-3) | 24 | at | Notre Dame OH | 31 | | D2 Playoff round 1 | PSAC |
| 11/30/2019 | Notre Dame OH | 20 | at | Kutztown (11-2) | 17 | | D2 Playoff Round 2 | at PSAC |
| 12/7/2019 | Notre Dame OH | 59 | at | Slippery Rock (13-1) | 65 | | D2 Quarterfinals | at PSAC |