| 9/1/2018 | Muskingum | 31 | at | Waynesburg (4-6) | 24 | at TPAC | ||
| 9/8/2018 | Muskingum | 14 | at | Ohio Northern (5-5,4-5) | 42 | |||
| 9/15/2018 | Marietta (7-3,6-3) | 46 | at | Muskingum | 20 | |||
| 9/22/2018 | Muskingum | 31 | at | Wilmington (1-9,0-9) | 24 | |||
| 9/29/2018 | John Carroll (9-2,8-1) | 44 | at | Muskingum | 7 | |||
| 10/13/2018 | Muskingum | 7 | at | Baldwin-Wallace (8-2,7-2) | 44 | |||
| 10/20/2018 | Otterbein (2-8,1-8) | 14 | at | Muskingum | 21 | |||
| 10/27/2018 | Muskingum | 41 | at | Heidelberg (5-5,4-5) | 14 | |||
| 11/3/2018 | Mount Union (14-1,9-0) | 52 | at | Muskingum | 10 | |||
| 11/10/2018 | Capital (3-7,3-6) | 33 | at | Muskingum | 28 |
| vs Muskingum | vs Other Opponents | Muskingum compared to OOs | |
| Record: | 6-4 | 52-44 | |
| Points Scored: | 33.70 | 30.46 | -3.24 |
| Points Allowed: | 21.00 | 28.59 | -7.59 |
| Margin: | 12.70 | 1.87 | -10.83 |
| Total Points: | 54.70 | 59.05 | -4.35 |