| 9/1/2018 | McNeese State | 17 | at | Northern Colorado (2-9) | 14 | at BSky | ||
| 9/8/2018 | McNeese State | 51 | at | Houston Baptist (1-10,0-9) | 34 | |||
| 9/15/2018 | Nicholls State (9-4,7-2) | 10 | at | McNeese State | 20 | |||
| 9/22/2018 | McNeese State | 3 | at | BYU (7-6) | 30 | at Ind | ||
| 9/29/2018 | Stephen F. Austin (2-8,2-7) | 10 | at | McNeese State | 17 | |||
| 10/6/2018 | Abilene Christian (6-5,5-4) | 21 | at | McNeese State | 24 | |||
| 10/20/2018 | McNeese State | 17 | at | Incarnate Word (6-5,6-2) | 45 | |||
| 10/27/2018 | Central Arkansas (6-5,5-4) | 21 | at | McNeese State | 23 | |||
| 11/3/2018 | McNeese State | 6 | at | Southeastern Louisiana (4-7,4-5) | 23 | |||
| 11/10/2018 | McNeese State | 34 | at | Northwestern State (5-6,4-5) | 37 | OT | ||
| 11/17/2018 | Lamar (7-5,6-3) | 21 | at | McNeese State | 17 |
| vs McNeese State | vs Other Opponents | McNeese State compared to OOs | |
| Record: | 5-6 | 50-64 | |
| Points Scored: | 24.18 | 28.42 | 4.24 |
| Points Allowed: | 20.82 | 31.45 | -10.63 |
| Margin: | 3.36 | -3.03 | -6.39 |
| Total Points: | 45.00 | 59.87 | -14.87 |