| 8/25/2018 | Duquesne | 15 | at | Massachusetts (4-8) | 63 | at Ind | ||
| 9/1/2018 | Lock Haven (2-9) | 0 | at | Duquesne | 45 | PSAC (D2) | ||
| 9/8/2018 | Valparaiso (2-9) | 21 | at | Duquesne | 23 | Pio | ||
| 9/15/2018 | Dayton (6-5) | 26 | at | Duquesne | 31 | Pio | ||
| 9/22/2018 | Duquesne | 21 | at | Hawaii (8-6) | 42 | at MW | ||
| 10/6/2018 | Bryant (6-5,2-4) | 21 | at | Duquesne | 20 | |||
| 10/13/2018 | Robert Morris (2-9,0-6) | 24 | at | Duquesne | 48 | |||
| 10/20/2018 | Duquesne | 27 | at | St Francis PA (4-8,2-4) | 20 | |||
| 11/3/2018 | Duquesne | 47 | at | Wagner (4-7,3-3) | 30 | |||
| 11/10/2018 | Sacred Heart (7-4,5-1) | 24 | at | Duquesne | 28 | |||
| 11/17/2018 | Duquesne | 38 | at | Central Conn (6-5,4-2) | 31 | |||
| 11/24/2018 | Duquesne | 31 | at | Towson (7-5) | 10 | at CAAF | ||
| 12/1/2018 | Duquesne | 6 | at | South Dakota State (10-3) | 51 | 1AA Playoff Round 2 | at MVC |
| vs Duquesne | vs Other Opponents | Duquesne compared to OOs | |
| Record: | 4-9 | 64-74 | |
| Points Scored: | 27.92 | 30.78 | 2.86 |
| Points Allowed: | 29.23 | 33.15 | -3.92 |
| Margin: | -1.31 | -2.37 | -1.06 |
| Total Points: | 57.15 | 63.93 | -6.78 |