| 8/26/2017 | Missouri Baptist (3-8) | 7 | at | Lyon | 28 | MSFA | ||
| 9/2/2017 | Lyon | 28 | at | Hendrix (8-2) | 56 | at SAA | ||
| 9/9/2017 | Langston (10-1,8-0) | 41 | at | Lyon | 14 | |||
| 9/16/2017 | Lyon | 61 | at | Trinity Bible (1-5) | 0 | at None | ||
| 9/23/2017 | Lyon | 21 | at | Panhandle State (7-3,6-2) | 42 | |||
| 9/30/2017 | Wayland Baptist (4-6,4-4) | 30 | at | Lyon | 28 | |||
| 10/7/2017 | Lyon | 17 | at | Arizona Christian (7-3,5-3) | 56 | |||
| 10/21/2017 | Texas Wesleyan (0-11,0-8) | 14 | at | Lyon | 21 | |||
| 10/28/2017 | Lyon | 13 | at | Southwestern Assemblies of God (8-3,7-1) | 28 | |||
| 11/4/2017 | Bacone (2-9,2-6) | 14 | at | Lyon | 34 | |||
| 11/11/2017 | Lyon | 41 | at | Texas College (1-9,1-7) | 3 |
| vs Lyon | vs Other Opponents | Lyon compared to OOs | |
| Record: | 6-5 | 45-55 | |
| Points Scored: | 26.45 | 25.19 | -1.26 |
| Points Allowed: | 27.82 | 30.66 | -2.84 |
| Margin: | -1.37 | -5.47 | -4.10 |
| Total Points: | 54.27 | 55.85 | -1.58 |