| 8/31/2017 | McNeese State (9-2,7-2) | 35 | at | Nicholls State | 37 | |||
| 9/9/2017 | Nicholls State | 14 | at | Texas A&M (7-6) | 24 | at SEC | ||
| 9/16/2017 | Prairie View (6-5) | 13 | at | Nicholls State | 44 | SWAC | ||
| 9/23/2017 | Nicholls State | 17 | at | Sam Houston (12-2,8-1) | 66 | |||
| 9/30/2017 | Nicholls State | 41 | at | Lamar (2-9,1-8) | 14 | |||
| 10/7/2017 | Northwestern State (4-7,4-5) | 10 | at | Nicholls State | 14 | |||
| 10/14/2017 | Abilene Christian (2-9,2-7) | 20 | at | Nicholls State | 29 | |||
| 10/28/2017 | Nicholls State | 38 | at | Incarnate Word (1-10,1-7) | 31 | |||
| 11/4/2017 | Houston Baptist (1-10,0-9) | 17 | at | Nicholls State | 23 | |||
| 11/11/2017 | Nicholls State | 34 | at | Stephen F. Austin (4-7,4-5) | 13 | |||
| 11/16/2017 | Nicholls State | 17 | at | Southeastern Louisiana (6-5,6-3) | 21 | |||
| 11/25/2017 | South Dakota (8-5) | 38 | at | Nicholls State | 31 | 1AA Playoff Round 1 | MVC |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 4-8 | 58-69 | |
| Points Scored: | 25.17 | 28.11 | 2.94 |
| Points Allowed: | 28.25 | 29.93 | -1.68 |
| Margin: | -3.08 | -1.82 | 1.26 |
| Total Points: | 53.42 | 58.04 | -4.62 |