| 9/10/2016 | Mt St Joseph (6-4) | 13 | at | DePauw | 44 | HCA | ||
| 9/17/2016 | DePauw | 35 | at | Wooster (4-6,4-5) | 24 | |||
| 9/24/2016 | Hiram (3-7,3-6) | 17 | at | DePauw | 66 | |||
| 10/1/2016 | Kenyon (3-7,2-7) | 35 | at | DePauw | 48 | |||
| 10/8/2016 | DePauw | 10 | at | Wittenberg (10-2,8-1) | 21 | |||
| 10/15/2016 | DePauw | 69 | at | Allegheny (1-9,1-8) | 21 | |||
| 10/22/2016 | Ohio Wesleyan (6-4,6-3) | 37 | at | DePauw | 15 | |||
| 10/29/2016 | Denison (8-2,7-2) | 16 | at | DePauw | 30 | |||
| 11/5/2016 | DePauw | 50 | at | Oberlin (0-10,0-9) | 17 | |||
| 11/12/2016 | DePauw | 37 | at | Wabash (8-2,7-2) | 34 |
| vs DePauw | vs Other Opponents | DePauw compared to OOs | |
| Record: | 2-8 | 47-45 | |
| Points Scored: | 23.50 | 25.86 | 2.36 |
| Points Allowed: | 40.40 | 25.99 | 14.41 |
| Margin: | -16.90 | -0.13 | 16.77 |
| Total Points: | 63.90 | 51.85 | 12.05 |