| 9/3/2016 | Ohio Wesleyan | 0 | at | Mary Hardin-Baylor (15-0) | 56 | at ASWC | ||
| 9/17/2016 | Wittenberg (10-2,8-1) | 33 | at | Ohio Wesleyan | 7 | |||
| 9/24/2016 | Ohio Wesleyan | 29 | at | Oberlin (0-10,0-9) | 16 | |||
| 10/1/2016 | Ohio Wesleyan | 14 | at | Denison (8-2,7-2) | 21 | |||
| 10/8/2016 | Kenyon (3-7,2-7) | 17 | at | Ohio Wesleyan | 25 | |||
| 10/15/2016 | Hiram (3-7,3-6) | 21 | at | Ohio Wesleyan | 28 | |||
| 10/22/2016 | Ohio Wesleyan | 37 | at | DePauw (8-2,7-2) | 15 | |||
| 10/29/2016 | Wabash (8-2,7-2) | 28 | at | Ohio Wesleyan | 0 | |||
| 11/5/2016 | Ohio Wesleyan | 24 | at | Allegheny (1-9,1-8) | 0 | |||
| 11/12/2016 | Wooster (4-6,4-5) | 14 | at | Ohio Wesleyan | 42 |
| vs Ohio Wesleyan | vs Other Opponents | Ohio Wesleyan compared to OOs | |
| Record: | 4-6 | 56-41 | |
| Points Scored: | 22.10 | 30.74 | 8.64 |
| Points Allowed: | 20.60 | 26.69 | -6.09 |
| Margin: | 1.50 | 4.05 | 2.55 |
| Total Points: | 42.70 | 57.43 | -14.73 |