| 9/1/2016 | Coast Guard | 34 | at | Anna Maria | 0 | @ ECFC | ||
| 9/2/2016 | Bridgewater State MA | 24 | at | Curry | 28 | MSCAC | ||
| Worcester Polytechnic | 37 | at | MIT | 34 | OT | LL | ||
| Western New England | 26 | at | Springfield | 10 | @ LL | |||
| Nichols | 21 | at | Westfield State | 34 | @ MSCAC | |||
| Salve Regina | 39 | at | Worcester State | 3 | @ MSCAC | |||
| 9/3/2016 | Endicott | 21 | at | Framingham State | 32 | @ MSCAC | ||
| SUNY-Maritime | 35 | at | Maine Maritime | 28 | OT | ECFC | ||
| 9/9/2016 | Anna Maria | 7 | at | Nichols | 22 | ECFC | ||
| 9/10/2016 | Merchant Marine | 31 | at | Coast Guard | 27 | LL | ||
| Hobart | 42 | at | Endicott | 20 | LL | |||
| Becker | 17 | at | MIT | 10 | ECFC | |||
| Westfield State | 7 | at | Western New England | 55 | MSCAC | |||
| 9/17/2016 | Nichols | 16 | at | Becker | 13 | @ ECFC | ||
| Salve Regina | 49 | at | Castleton State | 19 | @ ECFC | |||
| Catholic | 37 | at | Coast Guard | 35 | ODC | |||
| Anna Maria | 3 | at | Curry | 42 | ECFC | |||
| St Lawrence | 38 | at | Endicott | 0 | LL | |||
| Maine Maritime | 42 | at | Massachusetts Maritime | 35 | @ MSCAC | |||
| Rensselaer | 31 | at | MIT | 10 | LL | |||
| Western New England | 32 | at | Union NY | 16 | @ LL | |||
| 9/24/2016 | Nichols | 0 | at | Endicott | 37 | |||
| MIT | 30 | at | Maine Maritime | 13 | ||||
| Coast Guard | 10 | at | Salve Regina | 48 | ||||
| Curry | 28 | at | Western New England | 59 | ||||
| 10/1/2016 | Maine Maritime | 30 | at | Coast Guard | 36 | |||
| Salve Regina | 47 | at | Curry | 14 | ||||
| Endicott | 21 | at | MIT | 9 | ||||
| Western New England | 56 | at | Nichols | 27 | ||||
| 10/15/2016 | Curry | 54 | at | Coast Guard | 56 | |||
| Endicott | 35 | at | Maine Maritime | 14 | ||||
| Nichols | 14 | at | Salve Regina | 52 | ||||
| MIT | 0 | at | Western New England | 37 | ||||
| 10/22/2016 | Maine Maritime | 41 | at | Curry | 42 | |||
| Western New England | 20 | at | Endicott | 7 | ||||
| Coast Guard | 14 | at | Nichols | 24 | ||||
| MIT | 22 | at | Salve Regina | 35 | ||||
| 10/29/2016 | Salve Regina | 41 | at | Endicott | 20 | |||
| Coast Guard | 7 | at | MIT | 23 | ||||
| Curry | 35 | at | Nichols | 43 | ||||
| Maine Maritime | 25 | at | Western New England | 48 | ||||
| 11/5/2016 | Endicott | 28 | at | Coast Guard | 17 | |||
| Nichols | 54 | at | Maine Maritime | 28 | ||||
| Curry | 21 | at | MIT | 26 | ||||
| Western New England | 41 | at | Salve Regina | 22 | ||||
| 11/12/2016 | Endicott | 49 | at | Curry | 33 | |||
| Salve Regina | 45 | at | Maine Maritime | 12 | ||||
| MIT | 35 | at | Nichols | 36 | 2OT | |||
| Coast Guard | 29 | at | Western New England | 36 | ||||
| 11/19/2016 | Framingham State | 37 | at | Salve Regina | 34 | MSCAC | ||
| Husson | 27 | at | Western New England | 44 | ECFC | |||
| 11/26/2016 | Western New England | 24 | at | Alfred | 40 | @ E8 | ||
| Western New England | 24 | at | Alfred | 40 | @ E8 |