| 9/4/2015 | Stevenson (8-2) | 20 | at | North Carolina Wesleyan | 9 | MidAC | ||
| 9/12/2015 | Lincoln PA (3-7) | 28 | at | North Carolina Wesleyan | 17 | CIAA (D2) | ||
| 9/19/2015 | Shenandoah (4-6) | 30 | at | North Carolina Wesleyan | 17 | ODC | ||
| 10/3/2015 | North Carolina Wesleyan | 40 | at | Huntingdon AL (10-2,7-0) | 45 | |||
| 10/10/2015 | Maryville (8-2,5-2) | 7 | at | North Carolina Wesleyan | 24 | |||
| 10/17/2015 | North Carolina Wesleyan | 28 | at | Methodist (4-6,2-5) | 31 | |||
| 10/24/2015 | Greensboro (3-7,2-5) | 36 | at | North Carolina Wesleyan | 61 | |||
| 10/31/2015 | North Carolina Wesleyan | 56 | at | Averett (2-7,2-4) | 51 | |||
| 11/7/2015 | North Carolina Wesleyan | 48 | at | LaGrange (2-7,2-4) | 31 | |||
| 11/14/2015 | Ferrum (2-8,2-5) | 33 | at | North Carolina Wesleyan | 42 |
| vs North Carolina Wesleyan | vs Other Opponents | North Carolina Wesleyan compared to OOs | |
| Record: | 5-5 | 41-49 | |
| Points Scored: | 31.20 | 27.86 | -3.34 |
| Points Allowed: | 34.20 | 31.68 | 2.52 |
| Margin: | -3.00 | -3.82 | -0.82 |
| Total Points: | 65.40 | 59.54 | 5.86 |