| 9/4/2015 | Stevenson | 20 | at | North Carolina Wesleyan | 9 | MidAC | ||
| Averett | 35 | at | Washington and Lee | 63 | @ ODC | |||
| 9/5/2015 | Methodist | 18 | at | Apprentice | 0 | @ D3Ind | ||
| Ferrum | 7 | at | Emory & Henry | 55 | @ ODC | |||
| Guilford | 77 | at | Greensboro | 13 | ODC | |||
| Louisiana College | 35 | at | Huntingdon AL | 56 | ASWC | |||
| Birmingham-Southern | 29 | at | LaGrange | 28 | SAA | |||
| Berry | 17 | at | Maryville | 43 | SAA | |||
| 9/10/2015 | Maryville | 28 | at | East Tennessee St | 21 | @ IndFCS (1AA) | ||
| 9/12/2015 | Randolph-Macon | 49 | at | Averett | 28 | ODC | ||
| LaGrange | 13 | at | Berry | 16 | 3OT | @ SAA | ||
| Huntingdon AL | 34 | at | Birmingham-Southern | 35 | @ SAA | |||
| Shenandoah | 42 | at | Ferrum | 27 | ODC | |||
| Bridgewater VA | 38 | at | Greensboro | 21 | ODC | |||
| Guilford | 55 | at | Methodist | 7 | ODC | |||
| Lincoln PA | 28 | at | North Carolina Wesleyan | 17 | CIAA (D2) | |||
| 9/19/2015 | Maryville | 30 | at | Emory & Henry | 13 | @ ODC | ||
| Hampden-Sydney | 55 | at | Ferrum | 24 | ODC | |||
| Greensboro | 42 | at | Gallaudet | 20 | @ ECFC | |||
| Averett | 21 | at | Guilford | 58 | @ ODC | |||
| Ave Maria | 28 | at | LaGrange | 21 | Sun (NAIA) | |||
| Randolph-Macon | 24 | at | Methodist | 31 | ODC | |||
| Shenandoah | 30 | at | North Carolina Wesleyan | 17 | ODC | |||
| 9/26/2015 | Huntingdon AL | 35 | at | Belhaven | 21 | @ ASWC | ||
| 10/2/2015 | Greensboro | 20 | at | Ferrum | 31 | |||
| 10/3/2015 | LaGrange | at | Averett | CCD | ||||
| North Carolina Wesleyan | 40 | at | Huntingdon AL | 45 | ||||
| Methodist | 23 | at | Maryville | 29 | ||||
| 10/10/2015 | Methodist | 33 | at | Averett | 41 | |||
| Huntingdon AL | 56 | at | Ferrum | 21 | ||||
| Greensboro | 25 | at | LaGrange | 27 | ||||
| Maryville | 7 | at | North Carolina Wesleyan | 24 | ||||
| 10/17/2015 | Averett | 46 | at | Greensboro | 48 | |||
| Huntingdon AL | 31 | at | LaGrange | 14 | ||||
| Ferrum | 37 | at | Maryville | 70 | ||||
| North Carolina Wesleyan | 28 | at | Methodist | 31 | ||||
| 10/24/2015 | Maryville | 31 | at | Averett | 26 | |||
| LaGrange | 27 | at | Ferrum | 24 | ||||
| Methodist | 6 | at | Huntingdon AL | 42 | ||||
| Greensboro | 36 | at | North Carolina Wesleyan | 61 | ||||
| 10/31/2015 | North Carolina Wesleyan | 56 | at | Averett | 51 | |||
| Huntingdon AL | 40 | at | Greensboro | 20 | ||||
| LaGrange | 31 | at | Maryville | 38 | ||||
| Ferrum | 32 | at | Methodist | 31 | ||||
| 11/7/2015 | Averett | 31 | at | Ferrum | 28 | OT | ||
| Methodist | 22 | at | Greensboro | 26 | ||||
| Maryville | 14 | at | Huntingdon AL | 38 | ||||
| North Carolina Wesleyan | 48 | at | LaGrange | 31 | ||||
| 11/14/2015 | Averett | 13 | at | Huntingdon AL | 44 | |||
| Greensboro | 3 | at | Maryville | 52 | ||||
| LaGrange | 12 | at | Methodist | 47 | ||||
| Ferrum | 33 | at | North Carolina Wesleyan | 42 | ||||
| 11/21/2015 | Hendrix | 27 | at | Huntingdon AL | 38 | NCAA D3 Championship - First Round | SAA | |
| 11/28/2015 | Huntingdon AL | 23 | at | Mary Hardin-Baylor | 43 | NCAA D3 Championship - Second Round | @ ASWC |