| 9/5/2015 | McNeese State | | at | LSU (9-3) | | | CCD | at SEC |
| 9/12/2015 | Incarnate Word (6-5,5-4) | 6 | at | McNeese State | 43 | | | |
| 9/19/2015 | McNeese State | 28 | at | Stephen F. Austin (4-7,4-5) | 14 | | | |
| 9/26/2015 | Mississippi College (2-8) | 0 | at | McNeese State | 37 | | | GSC (D2) |
| 10/3/2015 | McNeese State | 37 | at | Nicholls State (3-8,3-6) | 7 | | | |
| 10/10/2015 | Southeastern Louisiana (4-7,3-6) | 7 | at | McNeese State | 21 | | | |
| 10/17/2015 | McNeese State | 28 | at | Central Arkansas (7-4,7-2) | 13 | | | |
| 10/24/2015 | Northwestern State (4-7,4-5) | 27 | at | McNeese State | 47 | | | |
| 10/31/2015 | McNeese State | 15 | at | Abilene Christian (3-8,3-6) | 13 | | | |
| 11/7/2015 | Sam Houston (11-4,8-2) | 10 | at | McNeese State | 27 | | | |
| 11/21/2015 | McNeese State | 20 | at | Lamar (5-6,4-5) | 14 | | | |
| 12/5/2015 | Sam Houston (11-4,8-2) | 34 | at | McNeese State | 29 | | FCS Playoff Round 2 | |