| 9/1/2012 | Chattanooga (6-5) | 13 | at | South Florida | 34 | SoCon (1AA) | ||
| 9/8/2012 | South Florida | 32 | at | Nevada (7-6) | 31 | at MW | ||
| 9/13/2012 | Rutgers (9-4,5-2) | 23 | at | South Florida | 13 | |||
| 9/22/2012 | South Florida | 27 | at | Ball State (9-4) | 31 | at MAC | ||
| 9/29/2012 | Florida State (12-2) | 30 | at | South Florida | 17 | ACC | ||
| 10/6/2012 | South Florida | 28 | at | Temple (4-7,2-5) | 37 | |||
| 10/20/2012 | South Florida | 25 | at | Louisville (11-2,5-2) | 27 | |||
| 10/27/2012 | Syracuse (8-5,5-2) | 37 | at | South Florida | 36 | |||
| 11/3/2012 | Connecticut (5-7,2-5) | 6 | at | South Florida | 13 | |||
| 11/17/2012 | South Florida | 9 | at | Miami-Florida (7-5) | 40 | at ACC | ||
| 11/23/2012 | South Florida | 10 | at | Cincinnati (10-3,5-2) | 27 | |||
| 12/1/2012 | Pittsburgh (6-7,3-4) | 27 | at | South Florida | 3 |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 9-3 | 85-54 | |
| Points Scored: | 27.42 | 29.66 | 2.24 |
| Points Allowed: | 20.58 | 23.86 | -3.28 |
| Margin: | 6.84 | 5.80 | -1.04 |
| Total Points: | 48.00 | 53.52 | -5.52 |