Case Western Reserve Spartans

8-2 (1-2 University Athletic Association)

9/4/2010 John Carroll Blue Streaks 13 @ Case Western Reserve 30
9/11/2010 Case Western Reserve 14 @ Rochester Yellow Jackets 10
9/25/2010 Denison Big Red 7 @ Case Western Reserve 37
10/2/2010 Allegheny Gators 23 @ Case Western Reserve 24
10/9/2010 Case Western Reserve 48 @ Oberlin Yeomen 36
10/16/2010 Case Western Reserve 41 @ Hiram Terriers 0
10/23/2010 Wooster Scots 14 @ Case Western Reserve 28
10/30/2010 Case Western Reserve 20 @ Chicago Maroons 24 †
11/6/2010 Washington U Bears 14 @ Case Western Reserve 13 †
11/13/2010 Carnegie Mellon Tartans 0 @ Case Western Reserve 28 †