| 9/4/2010 | John Carroll 13 @ Case Western Reserve Spartans 30 | |
| 9/18/2010 | Mount Union Purple Raiders 51 @ John Carroll 7 | † |
| 9/25/2010 | Marietta Pioneers 18 @ John Carroll 24 | † |
| 10/2/2010 | John Carroll 28 @ Otterbein Cardinals 56 | † |
| 10/9/2010 | Wilmington Quakers 17 @ John Carroll 38 | † |
| 10/16/2010 | John Carroll 24 @ Muskingum Muskies 17 | † |
| 10/23/2010 | Ohio Northern Polar Bears 35 @ John Carroll 14 | † |
| 10/30/2010 | John Carroll 28 @ Capital Crusaders 20 | † |
| 11/6/2010 | John Carroll 35 @ Heidelberg Fighting Student Princes 37 | † |
| 11/13/2010 | Baldwin-Wallace Yellow Jackets 28 @ John Carroll 31 | † |