| 9/4/2010 | Endicott Power Gulls 33 @ Framingham State 27 3OT | † |
| 9/10/2010 | Framingham State 20 @ Nichols Bison 19 | † |
| 9/18/2010 | Salve Regina Seahawks 3 @ Framingham State 14 | † |
| 9/25/2010 | Framingham State 46 @ Bridgewater State MA Bears 7 | † |
| 10/2/2010 | Massachusetts Maritime Buccaneers 20 @ Framingham State 48 | † |
| 10/9/2010 | Framingham State 42 @ Fitchburg State Falcons 28 | † |
| 10/16/2010 | Maine Maritime Mariners 50 @ Framingham State 26 | † |
| 10/23/2010 | Framingham State 48 @ Westfield State Owls 27 | † |
| 10/30/2010 | Framingham State 34 @ Coast Guard Bears 13 | † |
| 11/6/2010 | Worcester State Lancers 21 @ Framingham State 42 | † |
| 11/20/2010 | Framingham State 27 @ Norwich Cadets 21 1OT (ECAC Northeast Bow) |