| 9/4/2010 | Endicott 33 @ Framingham State Rams 27 3OT | † |
| 9/11/2010 | Rensselaer Engineers 6 @ Endicott 3 | |
| 9/18/2010 | Endicott 56 @ Fitchburg State Falcons 14 | † |
| 9/25/2010 | Endicott 29 @ Salve Regina Seahawks 28 | † |
| 10/2/2010 | Curry Colonels 24 @ Endicott 28 | † |
| 10/9/2010 | Nichols Bison 10 @ Endicott 30 | † |
| 10/16/2010 | Endicott 3 @ Plymouth State Panthers 10 | † |
| 10/23/2010 | Endicott 37 @ UMass Dartmouth Corsairs 13 | † |
| 10/30/2010 | Western New England Golden Bears 15 @ Endicott 23 | † |
| 11/6/2010 | MIT Engineers 7 @ Endicott 38 | † |
| 11/13/2010 | Endicott 38 @ Maine Maritime Mariners 35 | † |
| 11/20/2010 | Endicott 35 @ Cortland Red Dragons 49 (D3 Playoffs Round 1) |