| 9/4/2010 | Plymouth State 16 @ Castleton State Spartans 14 | |
| 9/11/2010 | Mount Ida Mustangs 41 @ Plymouth State 16 | |
| 9/18/2010 | Plymouth State 17 @ Bridgewater State MA Bears 0 | † |
| 9/25/2010 | Plymouth State 33 @ UMass Dartmouth Corsairs 9 | † |
| 10/2/2010 | Nichols Bison 0 @ Plymouth State 17 | † |
| 10/9/2010 | Plymouth State 21 @ MIT Engineers 7 | † |
| 10/16/2010 | Endicott Power Gulls 3 @ Plymouth State 10 | † |
| 10/23/2010 | Western New England Golden Bears 14 @ Plymouth State 6 | † |
| 10/30/2010 | Plymouth State 14 @ Salve Regina Seahawks 30 | † |
| 11/6/2010 | Curry Colonels 24 @ Plymouth State 21 1OT | † |