| 9/3/2010 | Augustana IL Vikings 28 @ Greenville 7 | |
| 9/11/2010 | Anderson Ravens 35 @ Greenville 41 | |
| 9/18/2010 | Greenville 10 @ Albion Britons 35 | |
| 9/25/2010 | Greenville 17 @ Millikin Big Blue 27 | |
| 10/2/2010 | Martin Luther Knights 9 @ Greenville 10 | † |
| 10/9/2010 | Greenville 35 @ St Scholastica Saints 7 | † |
| 10/16/2010 | MacMurray Highlanders 7 @ Greenville 50 | † |
| 10/23/2010 | Greenville 30 @ Westminster MO Blue Jays 21 | † |
| 10/29/2010 | Greenville 51 vs Crown Storm 20 (Minneapolis MN) | † |
| 11/6/2010 | Eureka Red Devils 27 @ Greenville 62 | † |