| 9/4/2010 | Millikin 42 @ Illinois College Blue Boys 31 | |
| 9/18/2010 | Hope Flying Dutchmen 21 @ Millikin 31 | |
| 9/25/2010 | Greenville Panthers 17 @ Millikin 27 | |
| 10/2/2010 | Augustana IL Vikings 28 @ Millikin 24 | † |
| 10/9/2010 | Millikin 24 @ Carthage Red Men 48 | † |
| 10/16/2010 | Millikin 7 @ North Central Cardinals 38 | † |
| 10/23/2010 | Elmhurst Bluejays 40 @ Millikin 34 | † |
| 10/30/2010 | Millikin 14 @ Illinois Wesleyan Titans 24 | † |
| 11/6/2010 | Millikin 16 @ North Park Vikings 7 | † |
| 11/13/2010 | Wheaton Thunder 46 @ Millikin 0 | † |